We present a new version of ReLoC: a relational separation logic for proving refinements of programs with higher-order state, fine-grained concurrency, polymorphism and recursive types. The core of ReLoC is its refinement judgment $e \precsim e' : \tau$, which states that a program $e$ refines a program $e'$ at type $\tau$. ReLoC provides type-directed structural rules and symbolic execution rules in separation-logic style for manipulating the judgment, whereas in prior work on refinements for languages with higher-order state and concurrency, such proofs were carried out by unfolding the judgment into its definition in the model. ReLoC's abstract proof rules make it simpler to carry out refinement proofs, and enable us to generalize the notion of logically atomic specifications to the relational case, which we call logically atomic relational specifications. We build ReLoC on top of the Iris framework for separation logic in Coq, allowing us to leverage features of Iris to prove soundness of ReLoC, and to carry out refinement proofs in ReLoC. We implement tactics for interactive proofs in ReLoC, allowing us to mechanize several case studies in Coq, and thereby demonstrate the practicality of ReLoC. ReLoC Reloaded extends ReLoC (LICS'18) with various technical improvements, a new Coq mechanization, and support for Iris's prophecy variables. The latter allows us to carry out refinement proofs that involve reasoning about the program's future. We also expand ReLoC's notion of logically atomic relational specifications with a new flavor based on the HOCAP pattern by Svendsen et al.